Kaz Ishii (0-1) took over a 3-2 lead in the sixth and suffered a pair of nightmare innings, pitching to 17 hitters in 1.2 innings and taking the loss.
New York slugged a pair of homers off starter Hideo Nomo, one of which came from former Dodger minor leaguer Victor Diaz. Diaz and Mets' startng rightfielder Karim Garcia are former Dodger Baby Blue Rookies of the Year.
Los Angeles could manage only a pair of singles in three innings off Mets starter Tom Glavine.
In the bottom of the fourth inning Paul Lo Duca slashed a double to right-center and Juan Encarnacion homered (his first) to tie the game and Bubba Trammel followed with his first homer of the exhibition season.
Ishii, who had been undergoing a revamping of his pitching mechanics, took over in the top of the sixth but after retiring the first hitter on a grounder allowed a pair of singles and a pair of walks to tie the game. A sac fly gave NY the lead. Another single and another walk made it 5-3.
In the seventh, Ishii again got the first hitter on grounder, then gave up a walk, a double a fielder's choice and a homer, running the Mets' lead to 8-3. Doug Nickel took over to close out the inning.
Nickel and Duaner Sanchez pitched scoreless innings but the Dodgers could not overcome the New York advantage.
Ishii gave up six runs on five hits and four walks after the Dodger staff had given up only five walks in the first 36 innings of the season.
Cesar Izturis singled three times, the last hit coming in the fifth inning and it was the final Dodger hit of the game. NY pitching retired 14 of the final Los Angeles hitters, with only an error to mar the streak.
Juan Encarnacion added a single to his homer earlier in the game.
The Dodgers' two hottest hitters, James Loney and Jolbert Cabrera, did not play.
Dodgers sign 17
The Dodgers have come to terms on one-year contracts with outfielder Reggie Abercrombie, infielder Willy Aybar, right-hander Yhency Brazoban, right-hander Andrew Brown, outfielder Chin-Feng Chen, left-hander Steve Colyer, right-hander Jason Frasor, right-hander Joel Hanrahan, catcher Koyie Hill, shortstop Cesar Izturis, right-hander Edwin Jackson, left-hander Hong-Chih Kuo, left-hander Orlando Rodriguez, infielder/outfielder Jason Romano, catcher David Ross, outfielder Wilkin Ruan and infielder Joe Thurston.